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Damage increases to 1 heart in Chapter 4 and beyond. Isaac takes twelve hearts of damage from all sources.Įvery 45 seconds, a ticking will begin, and after 5 seconds, Isaac will take 1/2 heart of damage. Isaac takes a full heart of damage from all sources. Provides immunity to Curse of the Unknown. Provides immunity to Curse of the Labyrinth. Fetus, Mom's Eye, Technology, Loki's Horns, Mom's Knife, Brimstone, Technology 2, Epic Fetus, Monstro's Lung, The Ludovico Technique, Marked, Tech X, Trisagion, Spirit Sword, C Section. Each copy picked up has different effects and adds various excessive "gamer style" visual and sound effects to the gameplay.Įnables an item blacklist consisting of: Dr. Spawns a G FUEL! item in the starting room of each stage. Isaac leaves a trail of poop behind him as he walks. Completing a room multiple times does not yield additional pickups.īoss rooms lock Isaac in, similar to the Mom fight. At the end of the countdown, the trapdoor to the next floor appears.Įnemies, including bosses, respawn once Isaac leaves the room. When in a boss room, the boss's health bar is used as a timer and slowly ticks down. All rooms are considered cleared upon entering them doors stay open, room rewards spawn, Stonies instantly die. Isaac starts with 69 coins, but all items and consumables must be bought.Įnemies do not take damage. This includes pedestal items, shop purchases, devil deals, and the Cathedral/ Sheol boss chest. On the special seed selection menu, it is possible to remove a discovered seed by focusing it and pressing Q+E+Tab on keyboard or LB+RB+X on controller.Selecting multiple modes at once is also possible. Pressing Q / Left Bumper during character selection will bring up the Easter Egg Section, in which any previously unlocked game mode can be selected. Once a special seed has been entered, it will be permanently unlocked without needing to enter the code again.On the PC version pressing the I, O, and U keys during seed entry will replace them with 1, 0, and V respectively. All alphanumeric characters are accepted except for 5, I, O, and U.

Special seeds do not affect level generation.

This prevents any achievements from being obtained on that particular run.

Except for some special seeds, inputting a seed will cause the 'no trophies' mark to appear.

For example, if you find a Rebirth seed on PC, you can use it on the 3DS version and it will be the same because the 3DS version only has Rebirth.

Seeds will be the same on every platform as long as the game version is also the same.